Publication Name	World Journal of Gastroenterology
Manuscript ID	35979
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Promotion of Sema4D expression by tumor-associated macrophages: Significance in gastric carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Han Li, Jin-Shen Wang, Lin-Jun Mu, Ke-Shu Shan, Le-Ping Li and Yan-Bing Zhou
Funding Agency and Grant Number
Corresponding Author	Yan-Bing Zhou, PhD, Chief Doctor, Department of Gastrointestinal Surgery, Affilated Hospital of Qingdao University, Qingdao 266071, Shandong Province, China. didi8114@163.com
Key Words	Gastric carcinoma; CD68; Semaphorin 4D; Tumor-associated macrophages
Core Tip	This study explored the role and clinical significance of semaphorin 4D (Sema4D) expression promoted by tumor-associated macrophages (TAMs) in gastric carcinoma cells. By using immunohistochemical streptavidin-peroxidase method on tissue species and gastric carcinoma cells in non-contact co-culture with human M2 macrophages in vitro, we found that Sema4D protein expression was significantly higher in gastric carcinoma tissues than in adjacent normal tissues, and TAMs promoted the invasion and metastasis of gastric carcinoma cells possibly through upregulated Sema4D protein expression.
Citation	Li H, Wang JS, Mu LJ, Shan KS, Li LP, Zhou YB. Promotion of Sema4D expression by tumor-associated macrophages: Significance in gastric carcinoma. World J Gastroenterol 2018; 24(5): 593-601

Received	2017-08-26 22:08
Peer-Review Started	2017-08-27 02:30
To Make the First Decision	2017-09-13 00:54
Return for Revision	2017-09-13 02:44
Revised	2017-09-26 16:20
Second Decision	2017-11-21 11:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-21 18:53
Articles in Press	2017-11-21 18:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-04 01:26
Typeset the Manuscript	2018-01-15 08:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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