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11/12/2017 5:35:21 AM | Browse: 387 | Download: 576
Publication Name World Journal of Hepatology
Manuscript ID 36051
Country/Territory Italy
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Francesca Romana Ponziani, Irene Spinelli, Emanuele Rinninella, Lucia Cerrito, Antonio Saviano, Alfonso Wolfango Avolio, Michele Basso, Luca Miele, Laura Riccardi, Maria Assunta Zocco, Brigida Eleonora Annicchiarico, Matteo Garcovich, Marco Biolato, Giuseppe Marrone, Anna Maria De Gaetano, Roberto Iezzi, Felice Giuliante, Fabio Maria Vecchio, Salvatore Agnes, Giovanni Addolorato, Massimo Siciliano, Gian Lodovico Rapaccini, Antonio Grieco, Antonio Gasbarrini and Maurizio Pompili
Funding Agency and Grant Number
Corresponding Author Francesca Romana Ponziani, MD, Doctor, Internal Medicine, Gastroenterology, Hepatology, Agostino Gemelli Hospital, largo Agostino Gemelli 8, Rome 00168, Italy. francesca.ponziani@yahoo.it
Key Words Hepatocellular carcinoma; Barcelona Clinic Liver Cancer stage C; Cirrhosis; Alphafetoprotein; Disease control; Performance status; Survival
Core Tip Refining the prognosis of Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) is crucial to select patients that can get benefit from and be suitable for locoregional or surgical treatments. This study confirms that high AFP serum level and DC are the best predictors of mortality for BCLC C patients, highlighting that the effect of these two variables is reverse and dynamic, in a time dependent manner. Outstandingly, PS has not been found to be a strong predictor of mortality. According to our results, curative treatments should not be “a priori” excluded in a subset of BCLC stage C patients with favorable prognostic factors.
Citation Ponziani FR, Spinelli I, Rinninella E, Cerrito L, Saviano A, Avolio AW, Basso M, Miele L, Riccardi L, Zocco MA, Annicchiarico BE, Garcovich M, Biolato M, Marrone G, De Gaetano AM, Iezzi R, Giuliante F, Vecchio FM, Agnes S, Addolorato G, Siciliano M, Rapaccini GL, Grieco A, Gasbarrini A, Pompili M. Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma. World J Hepatol 2017; 9(36): 1322-1331 Available from: URL: http://www.wjgnet.com/1948-5182/full/v9/i36/1322.htm DOI: http://dx.doi.org/10.4254/wjh.v9.i36.1322
Received
2017-08-28 07:04
Peer-Review Started
2017-08-30 00:18
To Make the First Decision
2017-09-21 00:56
Return for Revision
2017-09-21 04:05
Revised
2017-09-28 15:44
Second Decision
2017-11-06 08:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-12 05:35
Articles in Press
2017-11-12 05:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-22 01:21
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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