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Publication Name World Journal of Gastroenterology
Manuscript ID 36223
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway mediated inflammation in mice
Manuscript Source Unsolicited Manuscript
All Author List Meng-Ping Jiang, Chun Xu, Yun-Wei Guo, Qian-Jiang Luo, Lin Li, Hui-Ling Liu, Jie Jiang, Hui-Xin Chen and Xiu-Qing Wei
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81470848
Breeding Foundation for Young Pioneers’ Research of Sun Yat-Sen University 14ykpy27
Corresponding Author Xiu-Qing Wei, PhD, Professor, Department of Digestive Disease, Third Affiliated Hospital, Sun Yet-Sen University, Tianhe Road No. 600, Tianhe District, Guangzhou 510630, Guangdong, China. weixq@mail.sysu.edu.cn
Key Words Lipopolysaccharide; Liver injury; β-arrestin 2; TLR4/NF-κB signaling pathway; Pro-inflammatory cytokines
Core Tip The role and mechanism of β-arrestin 2 in lipopolysaccharide (LPS) -induced liver injury remains unclear. In this study, β-arrestin 2 KO mice displayed more severe LPS-induced liver injury and significantly higher levels of pro-inflammatory cytokines than wild-type mice. Further, RAW264.7 cells treated with β-arrestin 2 siRNA expressed significantly higher pro-inflammatory cytokines and molecules involved in the TLR4/NF-κB signaling pathway [including phospho-IкBα (p-IкBα) and phosho-p65 (p-p65)] than the control group at 6 h after treatment with LPS. Therefore, β-arrestin 2 could protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB-mediated inflammation and may serve as a therapeutic target.
Citation Jiang MP, Xu C, Guo YW, Luo QJ, Li L, Liu HL, Jiang J, Chen HX, Wei XQ. β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice. World J Gastroenterol 2018; 24(2): 216-225
Received
2017-09-11 16:54
Peer-Review Started
2017-09-12 07:56
To Make the First Decision
2017-10-18 06:52
Return for Revision
2017-10-23 11:50
Revised
2017-11-03 07:37
Second Decision
2017-11-21 11:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-21 18:48
Articles in Press
2017-11-21 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-12-02 02:47
Typeset the Manuscript
2018-01-05 07:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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