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11/21/2017 6:41:31 PM | Browse: 252 | Download: 634
Publication Name World Journal of Gastroenterology
Manuscript ID 36285
Country/Territory China
Category Transplantation
Manuscript Type Basic Study
Article Title Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver-fibrosis rats ameliorates liver fibrosis
Manuscript Source Unsolicited Manuscript
All Author List Ling Lan, Ran Liu, Ling-Yun Qin, Peng Cheng, Bo-Wei Liu, Bing-Yong Zhang, Song-Ze Ding and Xiuling Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30900598
Basic and Advanced Technology Research Program of Henan Province 142300410380
Medical Science and Technology Project of Henan Province 201303211
Corresponding Author Ling Lan, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, the People’s Hospital of Zhengzhou University, the Henan Provicial People’s Hospital, 7 Weiwu Road, Zhengzhou 450003, Henan, China. lanling95@163.com
Key Words Bone marrow; Endothelial progenitor cells; Liver stem cell; Cell transplantation; Liver fibrosis
Core Tip In addition to liver regeneration, hepatic neovascularization and endothelial/sinusoidal remodeling are critical factors for the treatment of liver fibrosis. Bone marrow-derived endothelial progenitor cells (BM-EPCs) have shown to play a role in hepatic angiogenesis and be beneficial to liver fibrosis. However, BM-EPCs are all derived from healthy individuals in recent studies. Here we evaluated the feasibility to obtain normal BM-EPCs from rats with liver fibrosis, and the effectiveness of combined transplantation of BM-EPCs and bone marrow-derived hepatocyte stem cells for treating liver fibrosis in order to achieve the dual effects of hepatic neovascularization and liver regeneration.
Citation Lan L, Liu R, Qin LY, Cheng P, Liu BW, Zhang BY, Ding SZ, Li XL. Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis. World J Gastroenterol 2018; 24(2): 237-247
Received
2017-09-30 11:05
Peer-Review Started
2017-10-01 05:34
To Make the First Decision
2017-10-25 04:11
Return for Revision
2017-10-25 08:52
Revised
2017-11-06 14:31
Second Decision
2017-11-21 11:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-21 18:41
Articles in Press
2017-11-21 18:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-11-28 21:01
Typeset the Manuscript
2018-01-08 07:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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