Publication Name	World Journal of Gastroenterology
Manuscript ID	36331
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo and Ning Dai
Funding Agency and Grant Number
Corresponding Author	Ning Dai, PhD, Chief Doctor, Full Professor, Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. ndaicn@zju.edu.cn
Key Words	Fructo-oligosaccharide; Stress; Irritable bowel syndrome; Visceral hypersensitivity; Intestinal inflammation; Short chain fatty acids; FODMAP
Core Tip	Fructo-oligosaccharide is a component of Fermentable Oligosaccharides, Disaccharides, Mono­saccharides, and Polyols (FODMAP), which has been associated with triggering symptoms in patients with irritable bowel syndrome (IBS). In a stress-induced IBS mouse model, daily fructo-oligosaccharide (FOS) administration further intensified visceral hypersensitivity and low-grade intestinal inflammation compared to saline. FOS administration also led to increased intestinal production of individual and total short-chain fatty acids (SCFA) in mice subjected to stress. However, no difference in visceral sensitivity, intestinal inflammation, or cecal concentrations of SCFA was observed among sham-stressed mice receiving FOS or saline. Our findings suggest a mechanism of FODMAP-induced gastrointestinal symptoms associated with increased production of SCFA specific to IBS.
Citation	Chen BR, Du LJ, He HQ, Kim JJ, Zhao Y, Zhang YW, Luo L, Dai N. Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model. World J Gastroenterol 2017; 23(47): 8321-8333

Received	2017-09-28 00:49
Peer-Review Started	2017-09-28 07:27
To Make the First Decision	2017-10-18 07:26
Return for Revision	2017-10-19 03:19
Revised	2017-11-14 06:07
Second Decision	2017-11-21 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-21 18:44
Articles in Press	2017-11-21 18:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-02 00:05
Typeset the Manuscript	2017-12-07 10:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
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