Publication Name	World Journal of Gastroenterology
Manuscript ID	36385
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model
Manuscript Source	Unsolicited Manuscript
All Author List	Liang Sang, Xue-Mei Wang, Dong-Yang Xu, Li-Xuan Sang, Yan Han and Long-Yang Jiang
Funding Agency and Grant Number
Corresponding Author	Xue-Mei Wang, MD, Doctor, Department of Ultrasound, The First Hospital of China Medical University, NO. 155 Nanjing North ST., Shenyang 110001, Liaoning, China. wangxuemei@cmu1h.com
Key Words	Liver fibrosis; Rat; Morin; Nrf2
Core Tip	We constructed a liver fibrosis rat model with carbon tetrachloride (CCl4). The Sprague-Dawley rats were randomly divided into four groups: control group, morin group, CCl4 group, and morin + CCl4 group. α-SMA, collagen Ⅰ, collagen Ⅲ, NF-E2-related factor 2 (Nrf2), heme oxygenase (HO-1), and quinone oxidoreductase 1 (NQO1) were analyzed by real-time PCR and Western blot methods using frozen liver specimens. We found that morin could reduce hepatic fibrosis by inducing the expression of Nrf2 and its downstream antioxidant factors in the CCl4-induced rat liver fibrosis model.
Citation	Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY. Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model. World J Gastroenterol 2017; 23(47): 8334-8344

Received	2017-09-21 17:13
Peer-Review Started	2017-09-22 02:00
To Make the First Decision	2017-10-11 01:05
Return for Revision	2017-10-12 01:06
Revised	2017-10-20 08:59
Second Decision	2017-11-14 06:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-14 18:59
Articles in Press	2017-11-14 18:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-11-20 13:40
Typeset the Manuscript	2017-12-06 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
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