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Publication Name World Journal of Gastroenterology
Manuscript ID 36404
Country/Territory Japan
Category Oncology
Manuscript Type Retrospective Study
Article Title Early gastric cancer frequently has high expression of KK-LC-1, a cancer-testis antigen
Manuscript Source Unsolicited Manuscript
All Author List Nobue Futawatari, Takashi Fukuyama, Rui Yamamura, Akiko Shida, Yoshihito Takahashi, Yatsushi Nishi, Yoshinobu Ichiki, Hitoshi Yamazaki, Noritada Kobayashi and Masahiko Watanabe
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS KAKENHI 26670609
JSPS KAKENHI 21700510
JSPS KAKENHI 17K16578
Takeda Science Foundation
a Kitasato University Research Grant for Young Researchers
Grant-in-Aid for research by Kitasto University Medical Center H25-10
Corresponding Author Takashi Fukuyama, PhD, Academic Research, Research Scientist, Division of Biomedical Research, Kitasato University Medical Center, Arai 6-100, Kitamoto 364-8501, Japan. fukuyam@insti.kitasato-u.ac.jp
Key Words Gastric cancer; Cancer-testis antigen; Kitakyushu lung cancer antigen-1; Melanoma antigen-A1; Melanoma antigen-A3; New York esophageal cancer-1; Clinicopathological factor; Early stage
Core Tip The Kitakyushu lung cancer antigen-1 (KK-LC-1) is a relatively later cancer-testis antigen and has received interest because it was reported that KK-LC-1 is a predominant antigen for cancer immunotherapy. We found that the expression rate of KK-LC-1 in gastric cancer was 79.5%, which was higher than that of other cancer-testis antigens and the same as that in both early- and late-stage patients. KK-LC-1 is a potential biomarker for early detection of gastric cancer and identification of patients at high risk for gastric cancer. Furthermore, KK-LC-1 is a potential target for immunotherapy in gastric cancer.
Citation Futawatari N, Fukuyama T, Yamamura R, Shida A, Takahashi Y, Nishi Y, Ichiki Y, Kobayashi N, Yamazaki H, Watanabe M. Early gastric cancer frequently has high expression of KK-LC-1, a cancer-testis antigen. World J Gastroenterol 2017; 23(46): 8200-8206
Received
2017-10-05 16:59
Peer-Review Started
2017-10-06 09:35
To Make the First Decision
2017-10-18 06:48
Return for Revision
2017-10-19 09:00
Revised
2017-10-30 04:30
Second Decision
2017-11-14 06:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-14 18:53
Articles in Press
2017-11-14 18:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-04 11:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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