Publication Name	World Journal of Hepatology
Manuscript ID	36432
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management
Manuscript Source	Invited Manuscript
All Author List	Ranjit Chauhan, Shilpa Lingala, Chiranjeevi Gadiparthi, Nivedita Lahiri, Smruti R Mohanty, Jian Wu, Tomasz I Michalak and Sanjaya K Satapathy
Funding Agency and Grant Number
Corresponding Author	Sanjaya K Satapathy, FACG, FASGE, MBBS, MD, Associate Professor, Division of Transplant Surgery, Methodist University Hospital, University of Tennessee Health Sciences Center, 1211 Union Ave, Suite 340., Memphis, Tennessee 38104, United States. ssatapat@uthsc.edu
Key Words	Hepatitis B virus; Liver transplantation; Reactivation; Recurrence; Prophylaxis; Antivirals; Hepatitis B immunoglobulin
Core Tip	Aim of this review is to summarize the current concepts and management of hepatitis B after liver transplantation. There are no clear guidelines regarding hepatitis B therapy after transplantation. Hepatitis B immunoglobulin (HBIG) is expensive and cumbersome to administer and there is no definite time point for discontinuation of HBIG after liver transplantation. Here we summarize the indications and duration of hepatitis B immunoglobulin and nucleoside analogs. This review also addresses key molecular mechanisms and the risk factors which are associated with hepatitis B virus reactivation post liver transplantation. This review provides up-to-date information not only for the liver transplant specialists but also for the virologists and scientists working in this field.
Citation	Chauhan R, Lingala S, Gadiparthi C, Lahiri N, Mohanty SR, Wu J, Michalak TI, Satapathy SK. Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management. World J Hepatol 2018; 10(3): 352-370

Received	2017-11-02 03:12
Peer-Review Started	2017-11-02 04:22
To Make the First Decision	2017-11-23 02:19
Return for Revision	2017-11-27 02:40
Revised	2018-01-19 23:42
Second Decision	2018-02-01 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-02-09 03:11
Articles in Press	2018-02-09 03:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-19 17:45

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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