Publication Name	World Journal of Gastroenterology
Manuscript ID	36452
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	De-Rong Liu, Xiao-Juan Xu and Shu-Kun Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Key Technology Support Program during “12th Five-Year Plan” Period of China 2014BAI08B02
Corresponding Author	Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words	Leptin; Irritable bowel syndrome; Mast cells; Diarrhea; Visceral hypersensitivity
Core Tip	Leptin is an important cytokine that exerts significant biological effects on gastrointestinal function and immune system modulation. We found that diarrhea-predominant irritable bowel syndrome (IBS-D) patients had significantly increased psychological symptoms, visceral hypersensitivity, mucosal leptin expression, leptin mRNA expression, and mast cell activation rate. Additionally, leptin expression was positively correlated with anxiety, depression, and the mast cell activation rate, but negatively correlated with the defecation sensation threshold and maximum tolerance threshold during visceral sensitivity testing. Increased levels of mucosal leptin may interact with mast cells and the nervous system to contribute to the pathogenesis of IBS-D.
Citation	Liu DR, Xu XJ, Yao SK. Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2018; 24(1): 46-57

Received	2017-09-29 01:08
Peer-Review Started	2017-09-30 00:45
To Make the First Decision	2017-10-18 07:24
Return for Revision	2017-10-20 03:44
Revised	2017-11-08 08:49
Second Decision	2017-11-21 10:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-21 18:43
Articles in Press	2017-11-21 18:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-11-30 06:33
Typeset the Manuscript	2017-12-26 15:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com