Publication Name	World Journal of Hepatology
Manuscript ID	36960
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Management of restless legs syndrome in chronic liver disease: A challenge for the correct diagnosis and therapy
Manuscript Source	Invited Manuscript
All Author List	Rita Moretti, Paola Caruso, Marzia Tecchiolli, Silvia Gazzin and Claudio Tiribelli
Funding Agency and Grant Number
Corresponding Author	Rita Moretti, MD, PhD, Associate Research Scientist, Senior Scientist, Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste 34149, Italy. moretti@univ.trieste.it
Key Words	Restless legs syndrome; Chronic liver disease; Dopamine-agonist treatment; Augmentation
Core Tip	The diagnosis of restless legs syndrome relies on the presence of unpleasant sensation in the legs associated with the urge to move. Symptoms mostly begins during periods of rest or inactivity and worsens in the evening or night. The partial or total relief is related to movement. Chronic hepatic failure was recently described in association with RLS, but there are very limited studies with no mention to treatment. We describe RLS syndrome associated with well-defined chronic liver along with therapeutic options, discussing risks, benefits and potential side effects, with a particular look at the augmentation phenomenon in hepatic failure.
Citation	Moretti R, Caruso P, Tecchiolli M, Gazzin S, Tiribelli C. Management of restless legs syndrome in chronic liver disease: A challenge for the correct diagnosis and therapy. World J Hepatol 2018; 10(3): 379-387

Received	2017-10-30 15:12
Peer-Review Started	2017-10-31 08:48
To Make the First Decision	2017-12-26 00:24
Return for Revision	2017-12-26 07:40
Revised	2017-12-27 10:50
Second Decision	2018-01-16 06:41
Accepted by Journal Editor-in-Chief	2018-01-17 03:43
Accepted by Company Editor-in-Chief	2018-01-24 02:49
Articles in Press	2018-01-24 02:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-30 20:31
Typeset the Manuscript	2018-03-18 14:24

ISSN	1948-5182 (online)
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