Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	37188
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Evolution of transanal total mesorectal excision for rectal cancer: From top to bottom
Manuscript Source	Invited Manuscript
All Author List	Sameh Hany Emile, F Borja de Lacy, Deborah Susan Keller, Beatriz Martin-Perez, Sadir Alrawi, Antonio M Lacy and Manish Chand
Funding Agency and Grant Number
Corresponding Author	Manish Chand, BM BCh, BSc, FRCS (Gen Surg), PhD, Associate Professor, Surgeon, Department of Surgery and Interventional Sciences, GENIE Centre, University College London, 235 Euston Rd, London NW1 2BU, United Kingdom. mans001@aol.com
Key Words	Rectal cancer; Total mesorectal excision; Transanal total mesorectal excision; Transanal total mesorectal excision; Sphincter sparing surgery; Colorectal surgery
Core Tip	The evaluation and management of rectal cancer have evolved remarkably over the last few decades. Total mesorectal excision (TME) has been recognized as the standard surgical management for curative radical treatment of rectal cancer. While abdominal procedures, whether by the open or mini­mally invasive approaches, apply the classical concept of “top-to-bottom” dissection, the transanal TME (TaTME) uses the opposite approach of “bottom-to-top” dissection. In this review we discuss the evolution of TME for rectal cancer to the TaTME, its technical aspects, advantages, shortcomings, and current needs. The research and education initiatives as well as future directions of TaTME were also highlighted.
Citation	Emile SH, de Lacy FB, Keller DS, Martin-Perez B, Alrawi S, Lacy AM, Chand M. Evolution of transanal total mesorectal excision for rectal cancer: From top to bottom. World J Gastrointest Surg 2018; 10(3): 28-39

Received	2017-11-21 19:40
Peer-Review Started	2017-11-22 06:11
To Make the First Decision	2017-12-20 00:32
Return for Revision	2017-12-21 02:02
Revised	2018-01-07 13:43
Second Decision	2018-01-31 06:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-02-09 01:54
Articles in Press	2018-02-09 01:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-20 05:07

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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