Publication Name	World Journal of Cardiology
Manuscript ID	37201
Country	Japan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Remi Goto-Semba, Yuichi Fujii, Tomohiro Ueda, Chikage Oshita and Hiroki Teragawa
Funding Agency and Grant Number
Corresponding Author	Hiroki Teragawa, FACC, FACP, FAHA, MD, PhD, Chief Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku,, Hiroshima 732-0057, Japan. hiroteraga71@gmail.com
Key Words	Vasospastic angina; Acetylcholine; Brand-name drugs; Generic drugs; Refractory chest pain
Core Tip	Calcium-channel blockers (CCBs) are the first line of therapy for vasospastic angina (VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. Switching back to the original CCB improved the patients’ condition in both cases. Both cases involved highly severe VSA. It is important for cardiologists to check whether VSA patients who have refractory angina attacks while taking a CCB are taking a brand-name or generic CCB.
Citation	Goto-Semba R, Fujii Y, Ueda T, Oshita C, Teragawa H. Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports. World J Cardiol 2018; 10(3): 15-20

Received	2017-11-24 09:38
Peer-Review Started	2017-11-24 17:13
To Make the First Decision	2017-12-26 00:22
Return for Revision	2017-12-27 02:26
Revised	2018-01-12 23:45
Second Decision	2018-02-06 06:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-02-06 23:43
Articles in Press	2018-02-06 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-20 05:07

ISSN	1949-8462 (online)
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