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Publication Name World Journal of Hepatology
Manuscript ID 37206
Country/Territory Italy
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Cell fusion in the liver, revisited
Manuscript Source Invited Manuscript
All Author List Michela Lizier, Alessandra Castelli, Cristina Montagna, Franco Lucchini, Paolo Vezzoni and Francesca Faggioli
Funding Agency and Grant Number
Funding Agency Grant Number
Grant AMANDA “Alterazioni metaboliche, stress cellulari e processi neurodegenerativi” from Regione Lombardia/CNR Project to P.V. Castelli A is a recipient of a fellowship from Fondazione Nicola del Roscio
Corresponding Author Francesca Faggioli, PhD, Research Scientist, Istituto di Ricerca Genetica e Biomedica, CNR, via Fantoli 15/16, Milan 20138, Italy. francesca.faggioli@humanitasresearch.it
Key Words Cell fusion; Hepatocytes; TdTomato; Lineage tracing; Chimeras; Extracellular vesicles
Core Tip About 70% of hepatocytes are polyploid, arising either from genome duplication without division (endoreplication) or from cell fusion. Experiments with chimeric mice containing two cell populations each bearing a different genetic marker had shown that some liver cells express markers of both genomes, suggesting that cell fusion occurred. Here, we review the data in the literature and describe new experiments using a chimeric model that confirms that cell fusion contributes to liver polyploidy. We argue that the role of cell fusion in pathological conditions, such as viral hepatitis and neoplastic transformation, is worth further study.
Citation Lizier M, Castelli A, Montagna C, Lucchini F, Vezzoni P, Faggioli F. Cell fusion in the liver, revisited. World J Hepatol 2018; 10(2): 213-221
Received
2017-11-21 19:55
Peer-Review Started
2017-11-23 04:31
To Make the First Decision
2017-12-18 08:30
Return for Revision
2017-12-18 12:18
Revised
2017-12-28 08:30
Second Decision
2018-01-23 04:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-06 01:57
Articles in Press
2018-02-06 01:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-02-26 02:26
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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