Publication Name	World Journal of Hepatology
Manuscript ID	37238
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Survival outcomes of liver transplantation for hepatocellular carcinoma in patients with normal, high and very high preoperative alpha-fetoprotein levels
Manuscript Source	Invited Manuscript
All Author List	Wong Hoi She, Albert Chi Yan Chan, Tan To Cheung, Chung Mau Lo and Kenneth Siu Ho Chok
Funding Agency and Grant Number
Corresponding Author	Kenneth Siu Ho Chok, FRCS (Ed), Associate Professor, Department of Surgery, University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong , China. chok6275@hku.hk
Key Words	Alpha-fetoprotein; Liver transplantation; Recurrence; Survival
Core Tip	Various established criteria have been used to identify patients with hepatocellular carcinoma who would benefit from liver transplant with reasonable survival. Alpha-fetoprotein (AFP) level has been identified as an important factor associated with suboptimal survival with high recurrence rate. This study demonstrated that AFP level correlated well with the pathological findings of tumor differentiation and microvascular invasion, which are usually confirmed in explant pathology. In this set of data, AFP level of 54 ng/mL was associated with disease recurrence, and AFP level of 105 ng/mL was found to be the cut-off value for overall survival difference.
Citation	She WH, Chan ACY, Cheung TT, Lo CM, Chok KSH. Survival outcomes of liver transplantation for hepatocellular carcinoma in patients with normal, high and very high preoperative alpha-fetoprotein levels. World J Hepatol 2018; 10(2): 308-318

Received	2017-11-23 08:28
Peer-Review Started	2017-11-24 00:05
To Make the First Decision	2017-12-11 08:20
Return for Revision	2017-12-12 01:27
Revised	2017-12-18 08:54
Second Decision	2018-01-08 00:35
Accepted by Journal Editor-in-Chief	2018-01-08 01:25
Accepted by Company Editor-in-Chief	2018-02-05 23:06
Articles in Press	2018-02-05 23:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-26 07:16

ISSN	1948-5182 (online)
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