Publication Name	World Journal of Hepatology
Manuscript ID	37278
Country	Sweden

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied
Manuscript Source	Invited Manuscript
All Author List	Rui-Dong Duan
Funding Agency and Grant Number
Corresponding Author	Rui-Dong Duan, MD, PhD, Professor, Gastroenterology and Nutrition Lab, Department of Clinical Sciences, Lund University, Biomedical Center B11, Lund S22184, Sweden. rui-dong.duan@med.lu.se
Key Words	Sphingomyelin; Alk-SMase; NPP7; Autotaxin; Platelet-activating factor; Cholangiocarcinoma; Liver diseases; Gallstone
Core Tip	Alkaline sphingomyelinase is an enzyme expressing in the intestinal tract and additionally human liver. It hydrolyzes sphingomyelin, platelet activating factor and lysophospholipase. In the intestinal tract, it digests dietary sphingomyelin, stimulates cholesterol absorption, and inhibits development of colon cancer. Less is known about the implications of the enzyme in liver diseases. The review summarizes the current knowledge of its roles in hepatobiliary disease and raised special topics for future investigations.
Citation	Duan RD. Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied. World J Hepatol 2018; 10(2): 246-253

Received	2017-11-26 03:12
Peer-Review Started	2017-11-26 04:39
To Make the First Decision	2017-12-18 08:31
Return for Revision	2017-12-18 11:44
Revised	2018-01-13 10:10
Second Decision	2018-01-18 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-24 04:17
Articles in Press	2018-01-24 04:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-24 03:10

ISSN	1948-5182 (online)
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