Publication Name	World Journal of Hepatology
Manuscript ID	37331
Country	Pakistan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon?
Manuscript Source	Invited Manuscript
All Author List	Amna Subhan Butt, Fatima Sharif and Shahab Abid
Funding Agency and Grant Number
Corresponding Author	Shahab Abid, FACG, FCPS, MD, PhD, Professor, Section of Gastroenterology at Department of Medicine, Aga Khan University, Stadium Road, Karachi 74800, Pakistan. shahab.abid@aku.edu
Key Words	Hepatocellular carcinoma; Direct acting antivirals; Hepatitis C
Core Tip	The ground-breaking discovery of the new group of direct acting antiviral agents (DAAs) had led to a paradigm shift in the management of chronic hepatitis C (CHC). Wide variations have been observed in the studies assessing the long-term role of DAA based therapy on occurrence and recurrence of HCC. There is a need to differentiate weather the reported higher occurrence recurrence rates are due to DAA or host and disease related factors and to identify subset of individuals particularly at risk. Also, future investigations should be directed towards assessing the long-term effects of DAAs on group of patients that have not been studied thus far. Some important Centers in Europe and United States have been delaying antiviral treatment for 6 mo or more after the recent treatment for HCC. Hence, until more robust data is available, clinical practices should continue as per current guidelines in those patient groups who can benefit from DAA therapy with close surveillance of patients with advance fibrosis. Our aim is to consolidate the existing literature as well as to identify whether there is a particular subset of the population in which this phenomenon was witnessed.
Citation	Butt AS, Sharif F, Abid S. Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon? World J Hepatol 2018; 10(2): 267-276

Received	2017-12-05 09:49
Peer-Review Started	2017-12-05 23:10
To Make the First Decision	2018-01-15 03:29
Return for Revision	2018-01-15 07:57
Revised	2018-02-06 22:19
Second Decision	2018-02-08 08:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-02-09 03:03
Articles in Press	2018-02-09 03:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-26 10:21

ISSN	1948-5182 (online)
Open Access	Open-Access: This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com