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Publication Name World Journal of Hepatology
Manuscript ID 37412
Country/Territory France
Category Infectious Diseases
Manuscript Type Review
Article Title Hepatitis C virus: Morphogenesis, infection and therapy
Manuscript Source Invited Manuscript
All Author List Vladimir Alexei Morozov and Sylvie Lagaye
Funding Agency and Grant Number
Corresponding Author Sylvie Lagaye, DSc, PhD, Academic Research, Senior Scientist, Department of Immunology, Institut Pasteur, INSERM U1223, 25-28 rue du Dr Roux, Paris 75015, France. sylvie.lagaye@inserm.fr
Key Words Hepatitis C virus; Transmission; Molecular biology; Pathogenesis; In vitro and ex vivo models of hepatitis C virus infection; Treatment
Core Tip Brief overviews on epidemiology of hepatitis C virus (HCV), virus morphology and life cycle are presented. A special attention was focused on in vitro and in vivo models that are currently used to study the HCV infection. In fact, extensive use of existing models and creating a new ones is a way to reveal important events in the virus interaction with target cells. In particular, uncover of these interactions might shed light on the mechanism behind virus induced pathogenesis and chronicity, and by that contribute to the development of new drugs and prophylactic vaccines. Recently, the new multiple therapies with a pan-genotypic activity appeared on the market. It is worth mentioning, that there is no cross-resistance among the various classes of direct antiviral agents. The new agents (third generation) and even new targets (entry inhibitors, release inhibitors) being studied, should allow to cure all patients in the mid-term, hoping that they will have equal access to therapy.
Citation Morozov VA, Lagaye S. Hepatitis C virus: Morphogenesis, infection and therapy. World J Hepatol 2018; 10(2): 186-212
Received
2017-12-04 20:15
Peer-Review Started
2017-12-05 00:35
To Make the First Decision
2017-12-11 08:21
Return for Revision
2017-12-12 01:17
Revised
2018-01-11 12:39
Second Decision
2018-01-31 06:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-09 01:33
Articles in Press
2018-02-09 01:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-02-28 06:34
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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