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Publication Name World Journal of Gastroenterology
Manuscript ID 37423
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Clinical Practice Study
Article Title Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China
Manuscript Source Unsolicited Manuscript
All Author List Youhong Fang, Youyou Luo, Jindan Yu, Jingan Lou and Jie Chen
Funding Agency and Grant Number
Funding Agency Grant Number
Zhejiang Province Medical Platform Backbone 2017KY436
Corresponding Author Jie Chen, MD, Attending Doctor, Chief Doctor, Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, 3333 Bin Sheng Road, Hangzhou 310052, China, Hangzhou 310052, Zhejiang province, China. hzcjie@zju.edu.cn
Key Words Monogenic; very-early-onset inflammatory bowel disease; primary immunodeficiency diseases; IL10; IL10R
Core Tip This study is the largest study to analyze clinical differences between monogenic and non­monogenic very-early-onset inflammatory bowel disease (VEO-IBD) in China. Moreover, we characterized monogenic IBD phenotypically and genotypically through genetic testing (whole exome sequencing and targeted gene panel sequencing). We found a high proportion of monogenic IBD in the VEO-IBD group, with the most common monogenic IBD being IL10R mutation. Monogenic IBD and nonmonogenic IBD showed similar clinical features. Next-generation sequencing played an important role in the diagnosis of monogenic IBD.
Citation Fang YH, Luo YY, Yu JD, Lou JG, Chen J. Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China. World J Gastroenterol 2018; 24(9): 1035-1045
Received
2017-12-12 17:25
Peer-Review Started
2017-12-12 19:40
To Make the First Decision
2018-01-17 01:28
Return for Revision
2018-01-18 06:07
Revised
2018-01-31 02:52
Second Decision
2018-02-08 05:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-09 05:41
Articles in Press
2018-02-09 05:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-02-23 21:22
Typeset the Manuscript
2018-03-03 07:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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