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Publication Name World Journal of Gastroenterology
Manuscript ID 37663
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model.
Manuscript Source Unsolicited Manuscript
All Author List Yi-Fan Tong, Ning Meng, Miao-Qin Chen, Han-Ning Ying, Ming Xu, Billy Lu, Jun-Jie Hong, Yi-Fan Wang and Xiu-Jun Cai
Funding Agency and Grant Number
Funding Agency Grant Number
Major Scientific and Technological Project of Zhejiang Province 2015C03026
Corresponding Author Xiu-Jun Cai, FRSC, MD, Professor, Surgeon, Department of General Surgery, Sir Run Run Shaw Hospital, Schoole of Medicine, Zhejiang University, Qingchun East Road No.3, Hangzhou 310016, Zhejiang Province, China. srrsh_cxj@zju.edu.cn
Key Words Associating liver partition and portal vein ligation for staged hepatectomy; Liver regeneration; Hepatic progenitor cell; Function; Immature
Core Tip Despite the rapid proliferation of future liver remnant induced by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), the high mortality and morbidity remained alarming. A plausible reason was the functional proliferation lagged behind increase in volume. In this study, a rat model was established to evaluate the maturity of ALPPS-derived hepatocytes. Through the identification of hepatic characteristics, detection of liver function, and analysis of functional gene expression, we revealed the immaturity of ALPPS-derived proliferation in early regenerative response, which indicated volumetric assessment overestimated the functional proliferation. And clinically, the stage II of ALPPS should be performed prudently in patients with marginally adequate FLR, as the ALPPS-derived proliferation in volume lags behind the functional regeneration.
Citation Tong YF, Meng N, Chen MQ, Ying HN, Xu M, Lu B, Hong JJ, Wang YF, Cai XJ. Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model. World J Gastroenterol 2018; 24(10): 1107-1119
Received
2017-12-29 01:39
Peer-Review Started
2017-12-29 04:18
To Make the First Decision
2018-01-17 00:17
Return for Revision
2018-01-18 07:59
Revised
2018-02-04 15:59
Second Decision
2018-02-08 01:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-09 05:38
Articles in Press
2018-02-09 05:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-02-26 00:57
Typeset the Manuscript
2018-03-08 02:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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