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Publication Name World Journal of Gastroenterology
Manuscript ID 38483
Country/Territory Germany
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line
Manuscript Source Unsolicited Manuscript
All Author List Michael Carsten Gock, Christina Mullins, Christine Harnack, F Prall, Robert Ramer, Anja Goeder, OH Kramer, E Klar and Michael Linnebacher
Funding Agency and Grant Number
Corresponding Author Michael Linnebacher, PhD, Postdoc, Research Scientist, Department of General Surgery, Section of Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, Rostock 18055, Germany. michael.linnebacher@med.uni-rostock.de
Key Words Patient-derived tumor model; Large cell neuroendocrine carcinoma; Individualized medicine
Core Tip Since incidence of G3 poorly differentiated neuroendocrine carcinomas (NEC) is very low, data is substantially scarcer than on G1 or G2 neuroendocrine tumors. Herein we describe an ultra-low passage NEC cell line and corresponding patient-derived xenograft model established directly from patient derived colonic tumor samples. We characterized our model according to phenotype, molecular, morphological and growth characteristics, as well as drug response and radiation response profiles. We present a useful tool for further analysis of the biological characteristics and for development of novel diagnostic and therapeutic options for NEC. The model is available on request.
Citation Gock M, Mullins CS, Harnack C, Prall F, Ramer R, Göder A, Krämer OH, Klar E, Linnebacher M. Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. World J Gastroenterol 2018; 24(33): 3749-3759
Received
2018-02-28 23:48
Peer-Review Started
2018-03-01 01:36
To Make the First Decision
2018-04-11 06:50
Return for Revision
2018-04-18 03:14
Revised
2018-06-14 02:01
Second Decision
2018-06-15 07:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-16 06:08
Articles in Press
2018-06-16 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-31 09:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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