Publication Name	World Journal of Gastroenterology
Manuscript ID	38690
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib
Manuscript Source	Unsolicited Manuscript
All Author List	Masanori Ochi, Toshiro Kamoshida, Atsushi Ohkawara, Haruka Ohkawara, Nobushige Kakinoki, Shinji Hirai and Akinori Yanaka
Funding Agency and Grant Number
Corresponding Author	Masanori Ochi, MD, Doctor, Department of Gastroenterology, Hitachi General Hospital, 2-1-1, Jonancho, Hitachi 317-0077, Japan. maochi-tei@umin.ac.jp
Key Words	Hepatocellular carcinoma; Surrogate marker; Multikinase inhibitor-associated hand-foot skin reaction; Sorafenib; Intervention by pharmacists
Core Tip	Sorafenib is an oral anticancer drug associated with a high incidence of adverse reactions. However, no studies have evaluated its therapeutic efficacy under improved adherence. A surrogate marker of significant improvement in overall survival under improved adher­ence in advanced hepatocellular carcinoma patients after the introduction of sorafenib was multikinase inhibitor-associated hand-foot skin reaction. Intervention by healthcare providers, including pharmacists specializing in cancer treatment, has improved patient adherence, contributing to the true response to sorafenib treatment.
Citation	Ochi M, Kamoshida T, Ohkawara A, Ohkawara H, Kakinoki N, Hirai S, Yanaka A. Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib. World J Gastroenterol 2018; 24(28): 3155-3162

Received	2018-03-17 07:52
Peer-Review Started	2018-03-17 13:35
To Make the First Decision	2018-04-19 00:38
Return for Revision	2018-04-24 07:29
Revised	2018-05-09 13:50
Second Decision	2018-06-21 08:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-21 17:54
Articles in Press	2018-06-21 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-07-25 03:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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