Publication Name	World Journal of Clinical Cases
Manuscript ID	38709
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Polycystic kidney and hepatic disease 1 gene mutations in von Meyenburg complexes: Case report
Manuscript Source	Unsolicited Manuscript
All Author List	Su Lin, Tian-Yu Shang, Ming-Fang Wang, Jian Lin, Xiao-Jian Ye, Da-Wu Zeng, Jiao-Feng Huang, Nan-Wen Zhang, Yi-Long Wu and Yue-Yong Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Pilot Project of Fujian Science and Technology Department 2015Y0057 Fujian Medical Innovation Project 2018-ZQN-54 Science and Technology Project of Fujian Education Department JAT160211
Corresponding Author	Yue-Yong Zhu, MD, PhD, Professor, Liver Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20th, Taijiang District, Fuzhou 350005, Fujian Province, China. zhuyueyong@fjmu.edu.cn
Key Words	Von Meyenburg complexes; Ductal plate malformations; PKHD1; Gene mutation; Fibrosis
Core Tip	Von Meyenburg complexes (VMCs) are a rare type of ductal plate malformation. Although generally benign, VMCs have been found to correlate with malig­nant diseases and progress towards adenocarcinomas. Mutations of the PKHD1 gene have been demonstrated to cause autosomal recessive polycystic kidney disease, a type of ductal plate malformation. In this study, muta­tions of the PKHD1 gene located in exon 28 and exon 32, respectively, were identified in two Chinese VMCs families, with four VMCs patients reported in total.
Citation	Lin S, Shang TY, Wang MF, Lin J, Ye XJ, Zeng DW, Huang JF, Zhang NW, Wu YL, Zhu YY. Polycystic kidney and hepatic disease 1 gene mutations in von Meyenburg complexes: Case report. World J Clin Cases 2018; 6(9): 296-300

Received	2018-03-10 14:40
Peer-Review Started	2018-03-10 18:05
To Make the First Decision	2018-04-23 05:54
Return for Revision	2018-04-25 05:33
Revised	2018-05-04 10:58
Second Decision	2018-06-07 10:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-08 06:06
Articles in Press	2018-06-08 06:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-06-13 20:32
Typeset the Manuscript	2018-09-02 12:37

ISSN	2307-8960 (online)
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