Publication Name	World Journal of Psychiatry
Manuscript ID	38857
Country	Australia

Category	Psychiatry
Manuscript Type	Review
Article Title	Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders
Manuscript Source	Invited Manuscript
All Author List	Georgia M Parkin, Madhara Udawela, Andrew Gibbons and Brian Dean
Funding Agency and Grant Number
Corresponding Author	Georgia M Parkin, BSc, MSc, Molecular Psychiatry Laboratory, the Florey Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville 3052, VIC, Australia. georgia.parkin@florey.edu.au
Key Words	Glia; Excitatory amino acid transporter; Psychiatry; Affective disorders; Glutamate transporter; Glutamate; Schizophrenia
Core Tip	Following release from the presynaptic neuron, the majority of glutamate within the human cortex is taken up into glia cells where it is converted into glu­tamine for recycling back into glutamate. Glutamate transporters excitatory amino acid transporter (EAAT) 1 and EAAT2 are predominantly localized in the glial pl­asma membrane, and are responsible for the majority of glutamate uptake within the human brain. Here we provide a comprehensive review of the unique re­gula­tion of EAAT1 and EAAT2 mRNA and protein in health and psychiatric disorder, and in response to medication use.
Citation	Parkin GM, Udawela M, Gibbons A, Dean B. Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders. World J Psychiatr 2018; 8(2): 51-63

Received	2018-03-19 12:17
Peer-Review Started	2018-03-19 12:43
To Make the First Decision	2018-05-09 00:28
Return for Revision	2018-05-09 02:51
Revised	2018-05-15 04:36
Second Decision	2018-06-07 10:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-09 02:05
Articles in Press	2018-06-09 02:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-24 11:10

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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