Publication Name	World Journal of Gastroenterology
Manuscript ID	38863
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Identification of a five-long non-coding RNA signature to improve the prognosis prediction for patients with hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Qiu-Jie Zhao, Jiao Zhang, Lin Xu and Feng-Feng Liu
Funding Agency and Grant Number	Funding Agency Grant Number The National Nature Science Foundation of China 81702816 Shandong Provincial Natural Science Foundation ZR2017PH030
Corresponding Author	Qiu-Jie Zhao, PhD, Chief Doctor, Department of Gastroenterology, Shandong Provincial Hospital affiliated to Shandong University, No. 324, Jingwuwei 7th Road, Jinan 250021, Shandong Province, China. zhaoqiujiesdu@126.com
Key Words	Long non-coding RNA; Hepatocellular carcinoma; Prognosis; Survival prediction; Prognostic biomarker
Core Tip	In the present study, we developed a 5-long non-coding RNA (lncRNA) signature for predicting the prognosis of hepatocellular carcinoma (HCC) patients based on The Cancer Genome Atlas database. The signature was reproducible and robust in another independent large-scale HCC cohort, supporting its utility and effectiveness. In addition, the prognostic value of the 5-lncRNA signature was independent of clinicopathological variables. When compared with two previously identified signatures for HCC survival prediction, this 5-lncRNA signature showed superior prognostic power. Our study indicates that the 5-lncRNA signature could improve survival prediction and could be used as a prognostic biomarker for HCC patients.
Citation	Zhao QJ, Zhang J, Xu L, Liu FF. Identification of a five-long non-coding RNA signature to improve the prognosis prediction for patients with hepatocellular carcinoma. World J Gastroenterol 2018; 24(30): 3426-3439

Received	2018-03-27 03:31
Peer-Review Started	2018-03-28 02:33
To Make the First Decision	2018-05-09 04:37
Return for Revision	2018-05-12 08:22
Revised	2018-05-24 15:25
Second Decision	2018-06-21 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-21 17:53
Articles in Press	2018-06-21 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-02 00:39
Typeset the Manuscript	2018-08-09 00:24

ISSN	1007-9327 (print) and 2219-2840 (online)
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