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6/16/2018 6:04:21 AM | Browse: 301 | Download: 316
Publication Name World Journal of Gastroenterology
Manuscript ID 39151
Country/Territory United States
Category Oncology
Manuscript Type Minireviews
Article Title Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond
Manuscript Source Invited Manuscript
All Author List Emily M Lin, Jun Gong, Samuel J Klempner and Joseph Chao
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health 5K12CA001727-23
Corresponding Author Joseph Chao, MD, Assistant Professor, Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA 91010, United States. jchao@coh.org
Key Words Immunotherapy; Programmed cell death 1; Programmed death ligand 1; Microsatellite instablility; Gastric cancer
Core Tip Programmed death ligand 1 (PD-L1) and microsatellite instability have recently entered into clinical practice as recommended biomarker testing for the use of immune checkpoint inhibitors in gastroesophageal cancer. However, PD-L1 still does not carry the highest sensitivity and specificity with variability in testing reported. Incorporation of PD-L1 expression from the tumor microenvironment with counting of immune cells appears to be the most effective strategy to date. Future efforts focusing on composite biomarkers in ongoing research from combinatorial immuno-oncology strategies are necessary to drive the field forward.
Citation Lin EM, Gong J, Klempner SJ, Chao J. Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond. World J Gastroenterol 2018; 24(25): 2686-2697
Received
2018-03-30 08:42
Peer-Review Started
2018-03-30 11:22
To Make the First Decision
2018-05-17 03:15
Return for Revision
2018-05-21 03:59
Revised
2018-05-23 23:04
Second Decision
2018-06-15 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-16 06:04
Articles in Press
2018-06-16 06:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-07-03 03:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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