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Articles in Press
6/8/2018 4:31:02 AM | Browse: 164 | Download: 275
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Zhi Wang, Hai-Xia Cao, Jian-Neng Chen and Qin Pan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan ‘Precision Medicine Research’ |
No. 2017YFC0908903 |
| National Natural Science Foundation of China |
81070346 |
| National Natural Science Foundation of China |
81270492 |
| National Natural Science Foundation of China |
81470859 |
| National Natural Science Foundation of China |
81270491 |
| National Natural Science Foundation of China |
81470840 |
| State Key Development Program for Basic Research of China |
No. 2012CB517501 |
| 100 Talents Program |
No. XBR2011007h |
| Program of the Committee of Science and Technology |
No. 09140903500 |
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| Corresponding Author |
Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn |
| Key Words |
Non-alcoholic fatty liver disease; Patatin-like phospholipase domain-containing protein 3; Treatment; Lifestyle; Pharmacotherapy; Surgery; Polymorphism |
| Core Tip |
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 imposes universal, yet distinctly different, impact on various therapies in nonalcoholic fatty liver disease (NAFLD) patients. As compared to those with C-allele, patients with PNPLA3 rs738409 G-allele (PNPLA3 148M variant) show grater improvement in response to lifestyle modification, dipeptidyl peptidase-4 inhibitor ingestion, and bariatric surgery. In contrast, NAFLD patients carrying PNPLA3 rs738409 C-allele (PNPLA3 148I variant) are much sensitive to both omega-3 poly-unsaturated fatty acids and statin intervention. These diversities in treatment response warrant a personalized, precise medicine in NAFLD by stratification of PNPLA3 rs738409 genotype. |
| Citation |
Wang JZ, Cao HX, Chen JN, Pan Q. PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease. World J Clin Cases 2018; 6(8): 167-175 |
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Received |
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2018-04-24 02:32 |
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Peer-Review Started |
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2018-04-24 05:42 |
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To Make the First Decision |
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2018-05-11 01:10 |
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Return for Revision |
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2018-05-14 01:35 |
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Revised |
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2018-05-16 15:51 |
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Second Decision |
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2018-06-07 12:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-06-08 04:31 |
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Articles in Press |
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2018-06-08 04:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-08-13 07:21 |
| ISSN |
2307-8960 (online) |
| Open Access |
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| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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