Publication Name	World Journal of Stem Cells
Manuscript ID	39577
Country	Romania

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Murine models based on acute myeloid leukemia-initiating stem cells xenografting
Manuscript Source	Invited Manuscript
All Author List	Cristina Mambet, Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu and Carmen Cristina Diaconu
Funding Agency and Grant Number	Funding Agency Grant Number The project Competitiveness Operational Programme (COP) A1.1.4. No. P_37_798
Corresponding Author	Mihaela Chivu-Economescu, PhD, Research Assistant Professor, Research Scientist, Senior Researcher, Cellular and Molecular Pathology Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.chivu@gmail.com
Key Words	Acute myeloid leukemia; Leukemia-initiating stem cells; Antigen markers; Murine models; Xenografts
Core Tip	The review is aiming to introduce the field of acute myeloid leukemia (AML) pathogenesis, the concept of leukemic stem cells, and also to present the current attempts to develop best AML animal mo­dels as means to investigate the factors responsible for leukemic transformation. Due to difficulties in engraftment of less aggressive AML samples, it is currently being attempted to develop humanized mice by introducing supporting human stromal cells as a source of proper cytokines, in a challenge to mimic an appropriate bone marrow niche able to support le­ukemic stem cells engraftment.
Citation	Mambet C, Chivu-Economescu M, Matei L, Necula LG, Dragu DL, Bleotu C, Diaconu CC. Murine models based on acute myeloid leukemia-initiating stem cells xenografting. World J Stem Cells 2018; 10(6): 57-65

Received	2018-04-28 00:57
Peer-Review Started	2018-04-28 14:30
To Make the First Decision	2018-05-11 01:09
Return for Revision	2018-05-15 01:07
Revised	2018-05-24 11:15
Second Decision	2018-06-07 12:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-08 22:55
Articles in Press	2018-06-08 22:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-24 06:10

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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