Publication Name	World Journal of Clinical Cases
Manuscript ID	39646
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Risk factors for gastroesophageal reflux disease and analysis of genetic contributors
Manuscript Source	Invited Manuscript
All Author List	Alexandra Argyrou, Evangelia Legaki, Christos Koutserimpas, Maria Gazouli, Ioannis Papaconstantinou, George Gkiokas and George Karamanolis
Funding Agency and Grant Number
Corresponding Author	Maria Gazouli, PhD, Associate Professor, Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, Athens 11527, Greece. mgazouli@med.uoa.gr
Key Words	Single nucleotide polymorphisms; Genetic risk loci; Risk factors; Gastroesophageal reflux disease; Gastroesophageal reflux disease development
Core Tip	Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder, which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Several risk factors of GERD have been identified and evaluated over the years. Motor esophageal and gastric abnormalities, along with anatomical factors could contribute to GERD development. Genetic contributors seem to play a major role in GERD. Numerous single-nucleotide polymorphisms in various genetic loci have been men­tioned as potential risk factors. Further investigation on the risk genes may elucidate their exact function and role and demonstrate new therapeutic approaches to this increasingly common disease.
Citation	Argyrou A, Legaki E, Koutserimpas C, Gazouli M, Papaconstantinou I, Gkiokas G, Karamanolis G. Risk factors for gastroesophageal reflux disease and analysis of genetic contributors. World J Clin Cases 2018; 6(8): 176-182

Received	2018-05-03 02:27
Peer-Review Started	2018-05-04 03:04
To Make the First Decision	2018-05-21 02:33
Return for Revision	2018-05-22 00:35
Revised	2018-05-31 10:40
Second Decision	2018-06-07 12:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-08 14:55
Articles in Press	2018-06-08 14:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-10 07:51

ISSN	2307-8960 (online)
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