Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	41729
Country	United States

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Prevention of necrotizing enterocolitis in premature infants – an updated review
Manuscript Source	Invited Manuscript
All Author List	Yu-Ting Jin, Yue Duan, Xiao-Kai Deng and Jing Lin
Funding Agency and Grant Number
Corresponding Author	Jing Lin, MD, Associate Professor, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, United States. jing.lin@mssm.edu
Key Words	Necrotizing enterocolitis; Prevention; Human milk feeding; Probiotics; Empiric antibiotics; Standardized feeding protocols
Core Tip	In this review, we summarize some of the clinical practices recommended to reduce the risk of necrotizing enterocolitis (NEC) in premature infants. Firstly, it is evident that human milk feeding can reduce the incidence of NEC. Secondly, while most of the studies demonstrated that supplementation of probiotics can significantly reduce the incidence of NEC in premature infants, there are still some concerns in regards to the quality of probiotic preparations, safety, optimal dosage, and treatment duration. Thirdly, restricting initial empiric antibiotic use should be implemented in our daily practice to reduce the incidence of NEC. Lastly, standardized feeding protocols are recommended both for prevention of postnatal growth restriction and NEC.
Citation	Jin YT, Duan Y, Deng XK, Lin J. Prevention of necrotizing enterocolitis in premature infants – an updated review. World J Clin Pediatr 2019; 8(2): 23-32

Received	2018-08-25 09:04
Peer-Review Started	2018-08-25 11:02
To Make the First Decision	2018-10-08 07:28
Return for Revision	2018-10-10 00:51
Revised	2018-12-31 15:49
Second Decision	2019-01-22 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-28 23:40
Articles in Press	2019-01-28 23:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-02-08 21:35
Typeset the Manuscript	2019-03-14 06:42

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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