Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	41785
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Endoscopic evaluation of immunotherapy-induced gastrointestinal toxicity
Manuscript Source	Invited Manuscript
All Author List	Isabel Iranzo, Jose María Huguet, Patrícia Suárez, Luis Ferrer-Barceló, Vega Iranzo and Javier Sempere
Funding Agency and Grant Number
Corresponding Author	Jose María Huguet, PhD, Assistant Professor, Doctor, Digestive Disease Department, General University Hospital of Valencia, Avenida Tres Cruces, 2, Valencia 46014, Spain. huguet_jos@gva.es
Key Words	Enterocolitis; Ipilimumab; Immunotherapy; Immune-related adverse event; Nivolumab; Toxicity; Endoscopy
Core Tip	Widespread use of immunotherapy in various types of cancer has led to reports of new associated adverse effects resulting from increased stimulation of the immune system, which can confuse the body’s own tissues and organs with foreign matter, thus leading it to attack the body’s healthy tissue. The most frequent immune-mediated adverse effects include asthenia, general malaise, fever, gastrointestinal toxicity (abdominal pain, diarrhea, and colitis), cutaneous toxicity, hypothyroidism and hepatitis. This review of the endoscopic evaluation of immunotherapy-induced toxicity presents the most typical endoscopic images, the differential diagnosis based on these images, and the initial management.
Citation	Iranzo I, Huguet JM, Suárez P, Ferrer-Barceló L, Iranzo V, Sempere J. Endoscopic evaluation of immunotherapy-induced gastrointestinal toxicity. World J Gastrointest Endosc 2018; 10(12): 392-399

Received	2018-08-27 02:22
Peer-Review Started	2018-08-27 07:04
To Make the First Decision	2018-10-08 07:27
Return for Revision	2018-10-10 00:45
Revised	2018-11-20 15:13
Second Decision	2018-12-07 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-11 03:27
Articles in Press	2018-12-11 03:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-14 00:52

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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