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12/13/2018 5:41:16 PM | Browse: 283 | Download: 377
Publication Name World Journal of Gastroenterology
Manuscript ID 42534
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Increased expression of brain derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List Yu Zhang, Geng Qin, De-Rong Liu, Yan Wang and Shu-Kun Yao
Funding Agency and Grant Number
Funding Agency Grant Number
the National Key Technology Support Program during “12th Five-Year Plan” period of China 2014BAI08B00
the Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) Z171100001717008
Corresponding Author Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words Irritable bowel syndrome; Diarrhea; Brain-derived neurotrophic factor; Visceral hypersensitivity; Nerve growth
Core Tip This study comprehensively investigated the psychological and clinical characteristics and visceral sensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and further explored the levels of brain-derived neurotrophic factor (BDNF) protein and mRNA and nerve fiber density in the intestinal mucosa. It was demonstrated that the increased mucosal BDNF expression was positively correlated with the abdominal pain and disease severity and negatively correlated with visceral sensitivity parameters, which provides new evidence that BDNF may participate in the pathogenesis of IBS-D via facilitating mucosal nerve growth and increasing visceral sensitivity in IBS-D patients.
Citation Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
Received
2018-10-16 03:19
Peer-Review Started
2018-10-16 08:29
To Make the First Decision
2018-11-22 06:26
Return for Revision
2018-11-22 07:43
Revised
2018-12-03 15:43
Second Decision
2018-12-13 08:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-13 17:41
Articles in Press
2018-12-13 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-20 12:39
Typeset the Manuscript
2019-01-14 00:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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