Publication Name	World Journal of Gastroenterology
Manuscript ID	43054
Country	China

Category	Transplantation
Manuscript Type	Retrospective Study
Article Title	Safety of hepatitis B virus core antigen-positive grafts in liver transplantation: A single-center experience in China
Manuscript Source	Unsolicited Manuscript
All Author List	Ming Lei, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Bo Li, Wen-Tao Wang, Hong Wu, Ming-Qing Xu, Zhe-Yu Chen and Yong-Gang Wei
Funding Agency and Grant Number
Corresponding Author	Lu-Nan Yan, MD, Professor, Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. yanlunan688@126.com
Key Words	Liver transplantation; Long-term outcome; Hepatitis B core antibody; Hepatitis B virus infection
Core Tip	Considering the shortage of suitable liver grafts for liver transplantation, using hepatitis B virus core antibody positive (HBcAb+) livers might be a possible way to enlarge the donor pool. However, the safety is controversial and not widely evaluated in Chinese patients. Our retrospective study enrolling 1071 patients found that HBcAb+ grafts did not affect the long-term outcome. Although post-transplant hepatitis B virus (HBV) infection had a relatively higher incidence in HBV surface antigen-negative patients with such grafts, it did not affect patient and graft survival. We also found that sufficient anti-HBs titers in recipients might be a protective factor against de novo HBV infection. Combined with proper postoperative antiviral prophylaxis, utilization of HBcAb+ grafts is feasible.
Citation	Lei M, Yan LN, Yang JY, Wen TF, Li B, Wang WT, Wu H, Xu MQ, Chen ZY, Wei YG. Safety of hepatitis B virus core antigen-positive grafts in liver transplantation: A single-center experience in China. World J Gastroenterol 2018; 24(48): 5525-5536

Received	2018-11-09 02:06
Peer-Review Started	2018-11-12 02:29
To Make the First Decision	2018-11-29 09:23
Return for Revision	2018-12-07 01:32
Revised	2018-12-08 02:31
Second Decision	2018-12-13 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-13 17:34
Articles in Press	2018-12-13 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-12-17 23:20
Typeset the Manuscript	2018-12-26 03:09

ISSN	1007-9327 (print) and 2219-2840 (online)
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