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12/12/2018 7:43:15 PM | Browse: 355 | Download: 450
Publication Name World Journal of Clinical Cases
Manuscript ID 43148
Country/Territory United Kingdom
Category Transplantation
Manuscript Type Observational Study
Article Title Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation
Manuscript Source Invited Manuscript
All Author List Evaldo Favi, Carmelo Puliatti, Rajesh Sivaprakasam, Mariano Ferraresso, Federico Ambrogi, Serena Delbue, Federico Gervasi, Ilaria Salzillo, Nicholas Raison and Roberto Cacciola
Funding Agency and Grant Number
Corresponding Author Evaldo Favi, MD, PhD, Senior Lecturer, Surgeon, Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza n.28, Milan 20122, Italy. evaldofavi@gmail.com
Key Words Polyomavirus; BK virus; Kidney transplantation; Outcome; Risk factors; Immunosuppression; Human leukocyte antigen; Rejection; Cytomegalovirus; Ethnicity
Core Tip Polyomavirus-associated nephropathy is a leading cause of kidney transplant failure. A systematic screening and treatment protocol in line with current international guideline was evaluated. Our results showed that despite early diagnosis and prompt intervention, graft-related outcomes for patients with BK-virus infection remain substantially inferior to control. We confirmed that initial viral load ≥ 10000 copies/mL is highly predictive of nephropathy. New putative risk factors for BK-viremia and nephropathy were also identified. Properly designed large multi-centre studies are warranted to further investigate individual susceptibility to BK-virus infection and validate alternative antiviral therapies.
Citation Favi E, Puliatti C, Sivaprakasam R, Ferraresso M, Ambrogi F, Delbue S, Gervasi F, Salzillo I, Raison N, Cacciola R. Incidence, risk factors, and outcome of BK polyomavirus infection after kidney transplantation. World J Clin Cases 2019; 7(3): 270-290
Received
2018-10-30 10:26
Peer-Review Started
2018-10-31 02:28
To Make the First Decision
2018-11-28 00:30
Return for Revision
2018-12-03 06:54
Revised
2018-12-08 15:04
Second Decision
2018-12-12 08:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-12 19:43
Articles in Press
2018-12-12 19:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-28 04:45
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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