Publication Name	World Journal of Gastroenterology
Manuscript ID	43325
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Osman Oguz Ahsen, Kaicheng Liang, Hsiang-Chieh Lee, Zhao Wang, James G Fujimoto and Hiroshi Mashimo
Funding Agency and Grant Number	Funding Agency Grant Number VA Boston Healthcare System R01-CA075289-21
Corresponding Author	Hiroshi Mashimo, MD, MSc, PhD, Associate Professor, Research Scientist, Gastroenterology Section, VA Boston Healthcare System, Harvard School of Medicine, 150 South Huntington Ave., Boston, MA 02130, United States. hmashimo@hms.harvard.edu
Key Words	Optical coherence tomography; Optical coherence tomography angiography; Radiofrequency ablation; Chronic radiation proctopathy; Rectal telangiectasia density scoring system; Subsurface microvascular imaging
Core Tip	In this study we use a prototype ultrahigh-speed optical coherence tomography (OCT) system and OCT angiography (OCTA) to perform depth-resolved visualization of microvasculature in the mucosal and submucosal layers of the rectum without requiring injected dyes. Abnormal distorted honeycomb patterns and ectatic/tortuous microvasculature in the rectal mucosa and heterogenous enlarged arterioles and venules > 200 μm in diameter in the submucosa are associated with chronic radiation proctopathy and resolved with radiofrequency ablation treatment. OCTA/OCT is a promising tool for investigating the pathophysiology of chronic radiation proctopathy and further studies are warranted to understand if it can help in clinical management.
Citation	Ahsen OO, Liang K, Lee HC, Wan Z, Fujimoto JG, Mashimo H. Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study. World J Gastroenterol 2019; 25(16): 1997-2009

Received	2018-11-10 08:37
Peer-Review Started	2018-11-12 02:09
To Make the First Decision	2018-12-29 00:53
Return for Revision	2018-12-29 06:14
Revised	2019-02-12 17:26
Second Decision	2019-02-15 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-02-16 02:53
Articles in Press	2019-02-16 02:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-04-17 09:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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