Publication Name	World Journal of Gastroenterology
Manuscript ID	44583
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Hu, Wei Hong, Kan-Nan Yao, Xiao-Hong Zhu, Zhi-Yun Chen and Lei Ye
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang province China LQ19H290001
Corresponding Author	Lei Ye, MAMS, Doctor, Department of Infectious Disease, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 YouDian Road, HangZhou 310006, Zhejiang Province, China. huj520@163.com
Key Words	Ursodeoxycholic acid; Hepatic lipid metabolism; AKT/mTOR/SREBP-1; Hepatic steatosis
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Many studies show that the disorder of hepatic lipid metabolism is major pathogenesis. Increased evidence indicates AKT/mTOR/SREBP-1 signaling pathway is a key pathway to regulate hepatocellular lipid metabolism. At present, there are few studies on the mechanism of NAFLD in hepatic lipid metabolism. We aimed to investigate the functional mechanism of ursodeoxycholic acid (UDCA) in oleic acid induced cellular models of NAFLD. The possible molecular mechanism and related targets of regulating hepatic lipid metabolism were explored, and the correlation between the occurrence of NAFLD and AKT/mTOR/SREBP-1 signaling pathway was explored. We provided more sufficient experimental basis for clinical application of UDCA in the treatment of NAFLD.
Citation	Hu J, Hong W, Yao KN, Zhu XH, Chen ZY, Ye L. Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. World J Gastroenterol 2019; 25(12):1492-1501

Received	2018-11-27 01:14
Peer-Review Started	2018-11-27 03:14
To Make the First Decision	2019-01-11 06:30
Return for Revision	2019-01-11 07:44
Revised	2019-01-29 07:33
Second Decision	2019-01-30 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-30 18:27
Articles in Press	2019-01-30 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-02-06 03:10
Typeset the Manuscript	2019-03-21 08:25

ISSN	1007-9327 (print) and 2219-2840 (online)
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