Publication Name	World Journal of Gastroenterology
Manuscript ID	44639
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dynamic changes of key metabolites during liver fibrosis in rats by ultra-performance liquid chromatography-mass spectrometry
Manuscript Source	Unsolicited Manuscript
All Author List	Jiong Yu, Jian-Qin He, De-Ying Chen, Qiao-Ling Pan, Jin-Feng Yang, Hong-Cui Cao and Lan-Juan Li
Funding Agency and Grant Number	Funding Agency Grant Number the Stem Cell and Translational Research, the National Key Research and Development Program of China 2016YFA0101001
Corresponding Author	Lan-Juan Li, MD, PhD, Academic Research, Doctor, Professor, Senior Researcher, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn
Key Words	Ultra-performance liquid chromatography-mass spectrometry; Metabonomics; Liver fibrosis; Biomarker; Cervonoyl ethanolamide; β-muricholic acid
Core Tip	Carbon tetrachloride induced model is stable and comparable with viral hepatitis. Dynamic changes reveal metabolic changes occur during the progression of fibrosis. We investigated the association of liver fibrosis with 21 metabolites, two of them, cervonoyl ethanolamide and β-muricholic acid, differed significantly in the fibrosis model rats compared to controls (P < 0.05) and showed prognostic value for fibrosis. The receiver operating characteristic results showed both two metabolites had excellent diagnostic value and could be used in clinical diagnosis in the future.
Citation	Yu J, He JQ, Chen DY, Pan QL, Yang JF, Cao HC, Li LJ. Dynamic changes of key metabolites during liver fibrosis in rats. World J Gastroenterol 2019; 25(8): 941-954

Received	2018-11-20 03:19
Peer-Review Started	2018-11-20 07:53
To Make the First Decision	2018-12-12 07:56
Return for Revision	2018-12-17 06:59
Revised	2019-01-10 07:32
Second Decision	2019-01-28 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-28 19:43
Articles in Press	2019-01-28 19:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-02-12 10:43
Typeset the Manuscript	2019-02-26 07:42

ISSN	1007-9327 (print) and 2219-2840 (online)
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