Publication Name	World Journal of Gastroenterology
Manuscript ID	45412
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Utility of linked color imaging for endoscopic diagnosis of early gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Toshihisa Fujiyoshi, Ryoji Miyahara, Kohei Funasaka, Kazuhiro Furukawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Takuya Ishikawa, Eizaburo Ohno, Masanao Nakamura, Hiroki Kawashima, Masato Nakaguro, Masahiro Nakatochi and Yoshiki Hirooka
Funding Agency and Grant Number
Corresponding Author	Ryoji Miyahara, MD, PhD, Associate Professor, Chief Doctor, Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-sho, Showa-ku, Nagoya 4668550, Japan. myhr@med.nagoya-u.ac.jp
Key Words	Linked color imaging; Early gastric cancer; Endoscopic submucosal dissection; Vessel density; Color difference
Core Tip	This study showed the utility of linked color imaging (LCI) for screening endoscopy of early gastric cancer and the concordant change in blood vessel density with redness in LCI image. The key results of the study were as follows: LCI gave better contrast than white light imaging for the color difference between cancer lesions and surrounding non-cancer tissue; an a* cutoff ≥ 24 for the value in Commission Internationale de l'Eclairage 1976 L*a*b* color space had good sensitivity and specificity for diagnosis of early gastric cancer; and surface blood vessel density in cancer lesions was significantly higher than that in non-cancer areas.
Citation	Fujiyoshi T, Miyahara R, Funasaka K, Furukawa K, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Nakaguro M, Nakatochi M, Hirooka Y. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer. World J Gastroenterol 2019; 25(10): 1248-1258

Received	2018-12-31 07:15
Peer-Review Started	2019-01-02 00:31
To Make the First Decision	2019-01-18 07:47
Return for Revision	2019-01-18 09:29
Revised	2019-02-15 06:46
Second Decision	2019-02-15 09:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-02-16 02:45
Articles in Press	2019-02-16 02:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-13 00:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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