Publication Name	World Journal of Gastroenterology
Manuscript ID	45490
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Hui Yang, Yu-xiang Zhang, Yang Gui, Jiang-Bo Liu, Jun-Jun Sun and Hua Fan
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China U1504815 the National Natural Science Foundation of China U1504808
Corresponding Author	Hua Fan, PhD, Academic Fellow, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, No. 24 Jing-Hua Road, Luoyang 471003, Henan Province, China. fanhua19851229@haust.edu.cn
Key Words	Pancreatic cancer; Autophagy-related protein microtubule-associated protein 1A/1B-light chain 3; Perineural invasion; Gene Ontology analysis; Kyoto Encyclopedia of Genes and Genomes pathway analysis; Ubiquitin C
Core Tip	In this study, we identified differentially expressed genes based on the autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 (LC3) to analyze the gene expression profile of autophagy in pancreatic cancer. Three hundred and forty-seven genes that have no confirmed association with the autophagy process of human pancreatic cancer cells in previous studies were concentrated, and the key pathways involved in autophagy were enriched. Furthermore, a key gene ubiquitin C which is closely related to the occurrence of perineural invasion (PNI) was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
Citation	Yang YH, Zhang YX, Gui Y, Liu JB, Sun JJ, Fan H. Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3. World J Gastroenterol 2019; 25(17): 2086-2098

Received	2019-01-09 09:19
Peer-Review Started	2019-01-10 03:26
To Make the First Decision	2019-02-26 07:54
Return for Revision	2019-02-26 09:02
Revised	2019-03-20 07:05
Second Decision	2019-04-04 08:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-10 22:05
Articles in Press	2019-04-10 22:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-04-22 08:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com