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Publication Name World Journal of Gastroenterology
Manuscript ID 45544
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Short hairpin RNA knockdown of nuclear factor erythroid 2-like 3 exhibits tumor-suppressing functions in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Miao-Mei Yu, Yue-Hua Feng, Lu Zheng, Jun Zhang and Guang-Hua Luo
Funding Agency and Grant Number
Funding Agency Grant Number
the Changzhou High-Level Medical Talents Training Project No.2016ZCLJ002
Corresponding Author Guang-Hua Luo, MD, PhD, Professor, Senior Researcher, Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Tianning District, Changzhou 213003, Jiangsu Province, China. shineroar@163.com
Key Words Nuclear factor erythroid 2-like 3; Hepatocellular carcinoma; The Cancer Genome Atlas; Short hairpin RNA; Epithelial-mesenchymal transition
Core Tip Nuclear factor erythroid 2-like 3 (NFE2L3), as a key regulator of the cellular stress response, is involved in the regulation of various tumor, whereas its physiological role in hepatocellular carcinoma (HCC) has not been elucidated. Our present study identified that NFE2L3 was closely associated with the grade and stage of HCC patients based on The Cancer Genome Atlas database. Furthermore, our study showed that short hairpin RNA knockdown of NFE2L3 exhibited tumor-suppressing functions in HCC.
Citation Yu MM, Feng YH, Zheng L, Zhang J, Luo GH. Short hairpin RNA-mediated knockdown of nuclear factor erythroid 2-like 3 exhibits tumor-suppressing effects in hepatocellular carcinoma cells. World J Gastroenterol 2019; 25(10): 1210-1223
Received
2019-01-04 05:48
Peer-Review Started
2019-01-04 07:30
To Make the First Decision
2019-01-23 03:36
Return for Revision
2019-01-24 02:21
Revised
2019-02-13 09:28
Second Decision
2019-02-15 09:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-16 02:44
Articles in Press
2019-02-16 02:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-02-20 02:40
Typeset the Manuscript
2019-03-13 00:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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