Publication Name	World Journal of Hepatology
Manuscript ID	45655
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Matthew Fasullo, Prashanth Rau, Dong-Qi Liu, Erik Holzwanger, Jomol P Mathew, Yurima Guilarte-Walker and Gyongyi Szabo
Funding Agency and Grant Number
Corresponding Author	Gyongyi Szabo, MD, N/A, PhD, Doctor, Professor, Department of Medicine, University of Massachusetts Medical School, 364 Planation Street, Worcester, MA 01605, United States. gyongyi.szabo@umassmed.edu
Key Words	Cirrhosis; Hepatic encephalopathy; Proton pump inhibitors; Hepatology; Proton pump inhibitor
Core Tip	In this study, we investigate if proton pump inhibitors (PPIs) use in patients with hepatic encephalopathy (HE) predisposes them to more severe stages of HE as per West Haven Criteria. We found that chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE as compared to patients with no PPI. Our data also indicated that cirrhotic patients on PPI have longer hospital stays, with increased morbidity and mortality during hospital stays.
Citation	Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol 2019; 11(6): 522-530

Received	2019-01-16 01:32
Peer-Review Started	2019-01-17 10:36
To Make the First Decision	2019-02-18 01:45
Return for Revision	2019-03-05 01:27
Revised	2019-06-05 13:53
Second Decision	2019-06-14 08:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-17 21:00
Articles in Press	2019-06-17 21:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-23 19:41
Typeset the Manuscript	2019-06-27 08:27

ISSN	1948-5182 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com