Publication Name	World Journal of Diabetes
Manuscript ID	45714
Country	Spain

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Insulin resistance is associated with subclinical vascular disease in humans
Manuscript Source	Unsolicited Manuscript
All Author List	María M Adeva-Andany, Eva Ameneiros-Rodríguez, Carlos Fernández-Fernández, Alberto Domínguez-Montero and Raquel Funcasta-Calderón
Funding Agency and Grant Number
Corresponding Author	María M Adeva-Andany, MD, PhD, Attending Doctor, Internal Medicine Department, Hospital General Juan Cardona, c/Pardo Bazán s/n, Ferrol 15406, Spain. madevaa@yahoo.com
Key Words	Diabetes; Cardiovascular risk; Arterial stiffness; Arterial elasticity; Intima-media thickness; Vascular calcification; Insulin resistance; Animal protein; Vegetable protein
Core Tip	Vascular injury associated to insulin resistance includes impaired vasodilation in response to chemical mediators, reduced distensibility of the arterial wall (arterial stiffness), vascular calcification, and increased thickness of the arterial wall. Vascular dysfunction associated to insulin resistance is present in asymptomatic subjects and predisposes to cardiovascular diseases, such as heart failure, ischemic heart disease, stroke, and peripheral vascular disease. Structural and functional vascular disease associated to insulin resistance is highly predictive of cardiovascular morbidity and mortality.
Citation	Adeva-Andany MM, Ameneiros-Rodríguez E, Fernández-Fernández C, Domínguez-Montero A, Funcasta-Calderón R. Insulin resistance is associated with subclinical vascular disease in humans. World J Diabetes 2019; 10(2): 63-77

Received	2019-01-16 08:05
Peer-Review Started	2019-01-17 10:21
To Make the First Decision	2019-01-26 07:17
Return for Revision	2019-01-28 01:11
Revised	2019-02-11 12:01
Second Decision	2019-02-12 03:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-02-12 03:47
Articles in Press	2019-02-12 03:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-14 05:23

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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