Publication Name	World Journal of Gastroenterology
Manuscript ID	45961
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Freeze-dried Si-Ni-San powder can ameliorate high-fat-diet-induced non-alcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Zhu, Yong-Min Li, Ting-Ting Feng, Yue Wu, Hai-Xia Zhang, Guo-Yin Jin and Jian-Ping Liu
Funding Agency and Grant Number
Corresponding Author	Yong-Min Li, MD, PhD, Full Professor, Department of Traditional Chinese Medicine, HeBei North University, NO.11, Diamond South Road, Zhangjiakou 075000, Hebei Province, China. zyxylym@hebeinu.edu.cn
Key Words	Nonalcoholic fatty liver disease; Si-Ni-San; High-fat diet; Intestinal microbiota; Inflammation
Core Tip	We studied the effects of Si-Ni-San freeze-dried powder on high-fat-diet-induced nonalcoholic fatty liver disease (NAFLD) in mice. We found that Si-Ni-San freeze-dried powder ameliorated high-fat-diet-induced NAFLD in mice, and the mechanism of action of Si-Ni-San freeze-dried powder against NAFLD may be associated with its anti-inflammatory and changing intestinal microbiota effects. Our findings provide some useful information for therapy of NAFLD.
Citation	Zhu F, Li YM, Feng TT, Wu Y, Zhang HX, Liu JP. Freeze-dried Si-Ni-San powder can ameliorate high-fat-diet-induced non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(24): 3056-3068

Received	2019-02-21 03:49
Peer-Review Started	2019-02-22 03:48
To Make the First Decision	2019-02-26 07:49
Return for Revision	2019-02-26 08:57
Revised	2019-05-28 12:42
Second Decision	2019-05-30 08:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-01 13:24
Articles in Press	2019-06-01 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-11 20:47
Typeset the Manuscript	2019-06-27 08:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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