Publication Name	World Journal of Stem Cells
Manuscript ID	46096
Country	South Korea

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Generation of mesenchymal stem-like cells for producing extracellular vesicles
Manuscript Source	Invited Manuscript
All Author List	Soo Kim and Tae Min Kim
Funding Agency and Grant Number	Funding Agency Grant Number Seoul National University
Corresponding Author	Tae Min Kim, DVM, PhD, Assistant Professor, Graduate School of International Agricultural Technology and Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang Daero 1447, Pyeongchang 25354, Gangwon-do, South Korea. taemin21@snu.ac.kr
Key Words	Mesenchymal stem cells; Extracellular vesicles; Preclinical studies; Exosomes
Core Tip	The therapeutic potential of extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) has recently been reported. However, alternative MSC sources are needed to produce EVs in a quality-controlled manner. Pluripotent stem cells-derived MSC-like cells can be robustly induced in vitro, and therefore induced MSC-like cells (iMSCs) have the possibility to become an alternative source for EV production. Herein, we review current data on iMSC generation, and provide key outcomes of their therapeutic functioning in preclinical studies.
Citation	Kim S, Kim TM. Generation of mesenchymal stem-like cells for producing extracellular vesicles. World J Stem Cells 2019; 11(5): 270-280

Received	2019-02-10 07:22
Peer-Review Started	2019-02-12 07:16
To Make the First Decision	2019-03-18 06:34
Return for Revision	2019-03-26 10:30
Revised	2019-04-02 05:54
Second Decision	2019-04-18 08:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-19 19:09
Articles in Press	2019-04-19 19:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-05-17 02:03

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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