Publication Name	World Journal of Gastroenterology
Manuscript ID	46163
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Diuretic window hypothesis in cirrhosis: Changing the point of view
Manuscript Source	Invited Manuscript
All Author List	Anderson Brito-Azevedo
Funding Agency and Grant Number
Corresponding Author	Anderson Brito-Azevedo, MD, MSc, Doctor, Liver Transplant Unit, Adventist Silvestre Hospital, 274 Ladeira do Ascurra st, Rio de Janeiro 22241-280, Brazil. andersonbrito.a@gmail.com
Key Words	Cirrhosis; Non-selective beta-blockers; Diuretic; Window hypothesis; Baveno; Cardiac output
Core Tip	The ‘window therapy hypothesis’ for non-selective beta-blockers treatment was consolidated based on weak evidences. Nevertheless, it was responsible to change clinical practice and even the Baveno consensus, about portal hypertension. In this opinion review we detail the studies assembled to compose the hypothesis, demonstrating that another factor could be behind results and outcomes observed, the diuretic treatment factor. We suggested so another hypothesis after cautiously analysis of evidences, the ‘diuretic window hypothesis’.
Citation	Brito-Azevedo A. The diuretic window hypothesis in cirrhosis: Changing the point of view. World J Gastroenterol 2019; 25(26): 3283-3290

Received	2019-02-03 14:37
Peer-Review Started	2019-02-06 05:48
To Make the First Decision	2019-04-08 01:13
Return for Revision	2019-04-08 03:14
Revised	2019-05-09 09:01
Second Decision	2019-05-30 08:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-01 13:26
Articles in Press	2019-06-01 13:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-11 00:33
Typeset the Manuscript	2019-07-13 11:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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