Publication Name	World Journal of Gastroenterology
Manuscript ID	46182
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Hong Jiang, Zhi-Yong Zhang, Xiao-Yan Wang, Xuan Tang, Hai-Long Liu, Ai-Li Wang, Hua-Guang Li, Er-Jiang Tang and Mou-Bin Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81874201 Shanghai Municipal Commission of Health and Family Planning ZK2015A32 Shanghai Municipal Commission of Health and Family Planning 201840359
Corresponding Author	Er-Jiang Tang, MSc, Statistician, Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, No. 450 Tengyue Road, Shanghai 200090, China. tangerjiang1988051@163.com
Key Words	Colorectal cancer; Lymphovascular invasion; Prognostic; DNA copy number aberration; Functional analysis
Core Tip	Lymphovascular invasion (LVI) is suggested to be an obligatory step in tumor progression toward metastasis, but its genetic mechanisms in colorectal cancer (CRC) have not been fully understood. This study showed that LVI was significantly associated with features of aggressive tumors and reduced survival in CRC, and its development might correlate with inflammation, epithelial-mesenchymal transition, angiogenesis and matrix remodeling. We also constructed a DNA copy number alteration classifier that could estimate the LVI status with high accuracy, which might contribute to the management of CRC.
Citation	Jiang HH, Zhang ZY, Wang XY, Tang Y, Liu HL, Wang AL, Li HG, Tang EJ, Lin MB. Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations. World J Gastroenterol 2019; 25(20): 2489-2502

Received	2019-02-02 09:17
Peer-Review Started	2019-02-06 09:20
To Make the First Decision	2019-03-14 06:21
Return for Revision	2019-03-15 03:05
Revised	2019-03-27 23:11
Second Decision	2019-04-19 07:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 02:04
Articles in Press	2019-04-20 02:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-04-30 19:23
Typeset the Manuscript	2019-05-25 07:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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