Publication Name	World Journal of Cardiology
Manuscript ID	46221
Country	United Kingdom

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: In vitro study
Manuscript Source	Unsolicited Manuscript
All Author List	Azar Hussain, Robert T Bennett, Zaheer Tahir, Emmanuel Isaac, Mubarak A Chaudhry, Syed Qadri, Mahmoud Loubani and Alyn H Morice
Funding Agency and Grant Number
Corresponding Author	Azar Hussain, MBBS, MD, MSc, Doctor, Lecturer, Surgeon, Department of Cardiothoracic Surgery, Castle Hill Hospital, Castle Road, Cottingham HU16 5JQ, United Kingdom. azar.hussain@hey.nhs.uk
Key Words	Heart failure; Atrial natriuretic peptide; Brain natriuretic peptide; In-vitro; Humans;
Core Tip	This study demonstrated that both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) vasodilate isolated human pulmonary artery rings and BNP acts as a partial agonist and inhibits the effects of ANP. The finding that addition of BNP inhibits the effects of ANP suggests that BNP does act as a partial agonist and could be advancing the progression to decompensated heart failure.
Citation	Hussain A, Bennett RT, Tahir Z, Isaac E, Chaudhry MA, Qadri SS, Loubani M, Morice AH. Differential effects of atrial and brain natriuretic peptides on human pulmonary artery: In vitro study. World J Cardiol 2019; 11(10):236-243

Received	2019-02-10 07:03
Peer-Review Started	2019-02-12 08:04
To Make the First Decision	2019-04-12 00:38
Return for Revision	2019-04-24 08:10
Revised	2019-08-31 11:07
Second Decision	2019-09-05 08:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-16 01:08
Articles in Press	2019-09-16 01:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-11 07:06
Typeset the Manuscript	2019-10-24 05:28

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com