Publication Name	World Journal of Gastroenterology
Manuscript ID	46303
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation
Manuscript Source	Invited Manuscript
All Author List	Richard PG Charlesworth and Michael N Marsh
Funding Agency and Grant Number
Corresponding Author	Richard PG Charlesworth, PhD, Lecturer, School of Science and Technology, University of New England, Armidale 2351, NSW, Australia. rcharle3@une.edu.au
Key Words	Coeliac disease; Histology; Diagnosis; 2-dimensional; 3-dimensional
Core Tip	The purpose of this review is to provide a definitive account of small intestinal mucosal structure and interpretation. We offer a critical account and give opinion that current testing protocols need to be altered. We then leave a framework regarding the true 3-dimensional knowledge of mucosal structure accrued over the 70-year period of study, and one which is available for future reference.
Citation	Charlesworth RPG, Marsh MN. From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation. World J Gastroenterol 2019; 25(20): 2402-2415

Received	2019-02-06 04:01
Peer-Review Started	2019-02-06 14:40
To Make the First Decision	2019-03-27 03:41
Return for Revision	2019-03-28 02:19
Revised	2019-04-04 20:52
Second Decision	2019-04-19 07:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 02:03
Articles in Press	2019-04-20 02:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-05-25 07:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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