Publication Name	World Journal of Gastroenterology
Manuscript ID	46439
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xue Yang, Zhi-Jie Xu, Xi Chen, Shuang-Shuang Zeng, Long Qian, Jie Wei, Mei Peng, Xiang Wang, Wan-Li Liu, Hong-Ying Ma, Zhi-Cheng Gong and Yuan-Liang Yan
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81803035, 81703036, 81572946 the China Postdoctoral Science Foundation 2017M610510 Youth Fund of Xiangya Hospital 2017Q17 the Postdoctoral Science Foundation of Central South University 185702
Corresponding Author	Zhi-Cheng Gong, PhD, Academic Fellow, Chief Pharmacist, Professor, Department of Pharmacy, Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China. gongzhicheng@csu.edu.cn
Key Words	Methylated septin 9; Methylated; Colorectal cancer; Diagnosis; Prognosis
Core Tip	This study retrospectively explored the value of serum septin 9 methylation (mSEPT9) in the diagnosis and prognosis of colorectal cancer in a Chinese population. Preoperative mSEPT9 levels in 354 enrolled patients were retrospectively analyzed. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 colorectal cancer cases from The Cancer Genome Atlas database were evaluated using bioinformatics analyses. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.
Citation	Yang X, Xu ZJ, Chen X, Zeng SS, Qian L, Wei J, Peng M, Wang X, Liu WL, Ma HY, Gong ZC, Yan YL. Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients. World J Gastroenterol 2019; 25(17): 2099-2109

Received	2019-02-14 01:28
Peer-Review Started	2019-02-15 09:35
To Make the First Decision	2019-03-06 01:34
Return for Revision	2019-03-08 01:57
Revised	2019-03-25 02:23
Second Decision	2019-04-04 08:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-10 21:26
Articles in Press	2019-04-10 21:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-04-28 00:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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