Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	46449
Country	United States

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Retrospective review of total neoadjuvant therapy
Manuscript Source	Unsolicited Manuscript
All Author List	Laila Babar, Veli Bakalov, Stephen Abel, Obaid Ashraf, Gene Grant Finley, Moses S Raj, Kristina Lundeen, Dulabh K Monga, Alexander V Kirichenko and Rodney E Wegner
Funding Agency and Grant Number
Corresponding Author	Laila Babar, MD, Doctor, Department of Internal Medicine, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, United States. laila.babar@ahn.org
Key Words	Total neoadjuvant therapy; Neoadjuvant chemoradiation; Multi-agent chemotherapy; Locally advanced rectal cancer; National cancer database; Colorectal cancer
Core Tip	Total neoadjuvant treatment (TNT) has been gaining favor as the treatment of choice for rectal carcinoma. It has been linked to better sphincter preservation and overall improved quality of life. Our study aim was to compare TNT with traditional chemotherapy and radiation over the last 10 years and evaluate for differences in outcome. Our study confirms a rising trend in the of use of TNT especially in patients diagnosed with locally advanced rectal cancer. Patients treated with TNT had higher burden of disease and despite this, they had similar survival outcomes as those treated with traditional chemotherapy and radiation.
Citation	Babar L, Bakalov V, Abel S, Ashraf O, Finley GG, Raj MS, Lundeen K, Monga DK, Kirichenko AV, Wegner RE. Retrospective review of total neoadjuvant therapy. World J Gastrointest Oncol 2019; 11(10): 857-865

Received	2019-02-27 03:29
Peer-Review Started	2019-02-27 12:12
To Make the First Decision	2019-04-12 00:45
Return for Revision	2019-04-24 07:16
Revised	2019-05-01 13:00
Second Decision	2019-09-12 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-12 17:07
Articles in Press	2019-09-12 17:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-12 11:32

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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