Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	46481
Country	United States

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism
Manuscript Source	Unsolicited Manuscript
All Author List	Alejandro Recio-Boiles, Sumana Veeravelli, Jessica Vondrak, Hani M Babiker, Aaron J Scott, Rachna T Shroff, Hitendra Patel, Emad Elquza and Ali McBride
Funding Agency and Grant Number
Corresponding Author	Alejandro Recio-Boiles, MD, Academic Fellow, Department of Medicine, Hematology and Medical Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ 85724, United States. areciomd@email.arizona.edu
Key Words	Direct oral anticoagulants; Low molecular weight heparin; Gastrointestinal cancer; Venous thromboembolism; Cancer associated thrombosis; Clinical risk
Core Tip	Our study shows similar efficacy of low molecular weight heparin as compared to apixaban and rivaroxaban. However, side effect profiles of these new direct oral anticoagulants (DOAC)’s may lead to a preferred use of apixaban, which had lower bleeding events in the highly sensitive gastrointestinal cancer (GICA) patient population. GICA-venous thromboembolism (VTE) is a high-risk patient subpopulation and warrants additional dedicated prospective clinical analysis of the efficacy and safety of DOACs. In addition, evaluation of clinical predictors that may influence the risk of VTE recurrence and major bleeding should include GICA as a high-risk group.
Citation	Recio-Boiles A, Veeravelli S, Vondrak J, Babiker HM, Scott AJ, Shroff RT, Patel H, Elquza E, Ali McBride A. Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism. World J Gastrointest Oncol 2019; 11(10): 866-876

Received	2019-02-26 06:58
Peer-Review Started	2019-02-27 12:53
To Make the First Decision	2019-08-01 00:14
Return for Revision	2019-08-21 03:34
Revised	2019-09-03 04:17
Second Decision	2019-09-12 09:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-12 16:39
Articles in Press	2019-09-12 16:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-23 06:26

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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